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Sunday, July 12, 2020 | History

2 edition of Fetal and postnatal development of glucuronide formation in mammalian tissue slices found in the catalog.

Fetal and postnatal development of glucuronide formation in mammalian tissue slices

Toivo Hirvonen

Fetal and postnatal development of glucuronide formation in mammalian tissue slices

by Toivo Hirvonen

  • 32 Want to read
  • 17 Currently reading

Published by Turun Yliopisto in Turku [Finland] .
Written in English

    Subjects:
  • Glucuronides -- Synthesis.,
  • Mammals -- Physiology.,
  • Tissue slices.

  • Edition Notes

    Bibliography: p. [64]-68.

    Statementby Toivo Hirvonen.
    SeriesTurun Yliopiston julkaisuja : Sarja A II, Biologica-geographica ;, 38
    Classifications
    LC ClassificationsAS262.T84 A28 no. 38, QP702.G57 A28 no. 38
    The Physical Object
    Pagination68 p. :
    Number of Pages68
    ID Numbers
    Open LibraryOL3135534M
    LC Control Number82462563

    After the first month of pregnancy, % of women reported alcohol consumption, % of women were drinking during all trimesters of pregnancy, and % during the third trimester.1 The prevalence of a very serious conglomerate of developmental and cognitive disabilities known as Fetal Alcohol Spectrum Disorders (FASD) is estimated to be as high as 2 to 5% of school children, making prenatal . 1. Biochem Pharmacol. Jul;15(7) Variations in glucuronide formation by perinatal liver. Dutton GJ. PMID: [PubMed - indexed for MEDLINE]Cited by:

      Glucuronidation of either an aliphatic or aromatic tertiary amine group in a molecule results in a quaternary ammonium–linked glucuronide metabolite (i.e. N +-glucuronide). The development of sound information on N +-glucuronide metabolites, including their characterization, has been slow. In part, this is because the presence of both the Cited by: The human fetal subplate has a complex structure and consists of various cellular, fibrillar and extracellular eleme Its composition is continuously changing throughout the midfetal, late fetal, perinatal, and early postnatal period However, in all these periods, the subplate consists of migratory and postmigratory neurons Cited by:

      During the last 20 years, new and exciting roles for glial cells in brain development have been described. Moreover, several recent studies implicated glial cells in the pathogenesis of neurodevelopmental disorders including Down syndrome, Fragile X syndrome, Rett Syndrome, Autism Spectrum Disorders, and Fetal Alcohol Spectrum Disorders (FASD). Abnormalities in glial cell development Cited by: Here we present a protocol for extraction and culture of neurons from adult rat or mouse CNS. The method proscribes an optimized protease digestion of slices Cited by:


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Fetal and postnatal development of glucuronide formation in mammalian tissue slices by Toivo Hirvonen Download PDF EPUB FB2

Hirvonen, Fetal and postnatal development of glucuronide formation in mammalian tissue slices Sarja-Series A. II () Biologica-Geographica Turku B. Jailing, L.-O. Boréus, A. Rane, F. SjÃqvist, Plasma concentrations of diphenylhydantoin in young infants by: HIRVONEN, T.

() Foetal and postnatal development of glucuronide formation in mammalian whole tissue slices. Acta physiol, scand. 68 (Suppl. ): HOAR, R. () Comparative Developmental Aspects of Selected Organ by: 3. Arch Dis Child. Oct;33() Insufficient glucuronide formation in the newborn and its relationship to the pathogenesis of icterus by:   Hirvonen T () Fetal and postnatal development of glucuronide formation in mammalian tissue slices.

Ann. Univ. Turku Sarja-Series A. 38Cited by: The appearance of morphine glucuronide in fetal plasma following maternal administration provides clear evidence that glucuronide metabolites can cross the primate placenta and result in significant fetal concentrations.

Fetal levels reach a plateau at concentrations that are 70 to 90 percent of maternal concentrations by 24 by: studies on the neonatal development of the glucuronide conjugating 1, 2 Audrey K. Brown 1 and Wolf W. Zuelzer 1 The Child Research Center of Michigan, the Department of Pediatrics, Wayne State University College of Medicine, and The Children's Hospital of Michigan Cited by: So far glucuronide synthesis has been found to occur in liver and to a lesser extent in kidney of a number of animal species.

Of the mammals studied cat liver slices formed very little glucuronide. More recently glucuronide formation has been discovered to occur in slices of gastrointestinal mucosa supplied with by: Glucuronic acid is donated by uridine diphosphate glucuronic acid (UDPGA), which serves as an endogenous substrate for the enzyme glucuronyl transferase.

Substrates for glucuronide formation are phenols, alcohols, carboxylic acids, amines, hydroxylamines, and mercaptans. The aims of this study were to: (1) segment the fetal hippocampal formation using T MR images from 41 specimens with gestational ages ranging.

Most of our understanding on the origin, specification and development of the female germ line in placental mammals comes from studies in the laboratory mouse. The molecular pathway leading to the development and establishment of the female germ line in mouse has erected as the paradigm for placental mammals.

It remains, however, largely unexplored whether the well Cited by: 1. Author Summary During mammalian fetal development, the precursor of the testis or ovary first appears as a simple thickening, in a specific region, of.

Author(s): Hirvonen,Toivo Title(s): Fetal and postnatal development of glucuronide formation in mammalian tissue slices. Country of Publication: Finland Publisher: Turku,   In contrast, glucuronidation of some substrates is catalyzed by the rat fetal liver in late gestation but not in the human fetal liver.

The deficient human fetal glucuronidation seems to be compensated for by early development of sulfation by: Glucuronide formation is the commonest conjugation in mammals, presumably from the ready availability of glucuronic acid in the tissues and the many chemical groups forming glucuronides.

Enzymes catalyzing glucuronide synthesis have been widely, if not deeply, studied and exhaustive references up to are available (Dutton, b).Cited by: to compliment FAEE analysis. Ethyl glucuronide (EtG) is another direct biomarker of ethanol that has been detected in meconium, placental tissue, and fetal remains of terminated pregnancies.

Whether these matrices contain EtG because it crosses the placenta or because the fetal liver converts ethanol to EtG is : Jeremy Matlow. Tracking Development of the Corpus Callosum in Fetal and Early Postnatal Baboons Using Magnetic Resonance The Open Neuroimaging Journal,5, (Suppl 2-M6)   Hirvonen, T.: Fetal and postnatal development of glucuronide formation in mammalian tissue slices.

Annales Universitatis Turkuensis, Sarja-Series Biologica Geographica 38 (). Google ScholarCited by:   A review of the literature that pertains to drug biotransformation in human fetal tissues reveals that, in spite of several publications in this comparatively new area of research, only very limited definitive information is currently available.

The large majority of the studies performed have dealt with the cytochrome Pdependent microsomal mono-oxygenase Cited by:   The glucuronide metabolites of several widely used drugs are detected in fetal plasma after maternal drug administration.

However, the disposition of these metabolites is poorly understood and clinical concerns have been raised about accumulation of active metabolites in the fetus. For this reason, morphineβ-glucuronide (M3G), an active metabolite of Cited by: A study was made of the o-aminophenol glucuronide synthesis in the slices of the liver, kidney and gastrointestinal tract after the administration of 3,4-benzpyrene, cinchophen, 3 Author: Kaarlo Hartiala.

"head to tail," dictates that development proceeds from the head to the lower part of the trunk An embryo's head, brain, and eyes develop earliest and are disproportionately large until the other parts catch up. At 2 months of gestation, the embryo's head is half the length of the body.Glucuronidation and Sulfonation Shipkova, M., et.

al. Acyl glucuronide drug metabolites; toxicological and analytical implications. Therapeutic Drug Monitor." formation of quaternary N-glucuronides, has received lots of attention because so manyFile Size: 3MB.Glucuronidation is a major pathway of xenobiotic biotransformation in most mammalian species, and requires the cofactor uridine diphosphate-glucuronic acid.

68, The reaction is metabolized by UGTs (also called glucuronyltransferases), which are present in many tissues. 68, The site of glucuronidation is generally an electron-rich nucleophilic heteroatom (oxygen, nitrogen, or sulfur).

68 Human UGTs are a family of enzymes that detoxify .